Inspirational manager Juergen Klopp has rekindled the Anfield flame though and delivered the club's 19th top-flight title, one behind arch-rivals United's record of 20, after finishing runners-up to City in a thrilling race last season.
The two previous meetings at Anfield ended in 4-0 and 3-1 defeats for Arsene Wenger's Arsenal teams, but there is a fresh optimism around the club after a successful transfer window.
Guardiola said City had plenty of options, with Gabriel Jesus the only main striker fit and ready but Ilkay Gundogan and Raheem Sterling are able to slot into the role.
Manchester United were held 1-1 at Wolverhampton Wanderers and missed out on taking top spot in the English Premier League.
IMAGES from the English Premier League matches played on Sunday
Spain striker Roberto Soldado's penalty on his Premier League debut gave Tottenham Hotspur a 1-0 win at Crystal Palace in their opening match of the season on Sunday.
Chelsea kept alive their remote Premier League title chances with a 2-0 win over London rivals Tottenham Hotspur on Sunday, set on their way by an exquisite strike from Hakim Ziyech which was quickly followed up by a Thiago Silva header.
Postal service worker Kristbjorn Hilmir Kjartansson and his friend Gretar Jonsson, a film student, took 14 days to make the trip from Reykjavik to Volgograd.
Arsenal's new manager Unai Emery faces a baptism of fire after the Gunners were handed an opening day fixture at home to Premier League champions Manchester City.
IMAGES from the English Premier League matches played on Saturday.
Images from the English Premier League matches played on Saturday.
A summary of Wednesday's action in the Premier League.
Champions Liverpool suffered a shock 1-0 defeat to lowly Burnley on Thursday, ending their 68 match unbeaten home record in the Premier League as their title defence continued to fade.
Cesc Fabregas kept alive Chelsea's hopes of finishing in the top four with a quickfire goal in a 1-0 win at Swansea City which leaves the Welsh side facing a major fight to retain their Premier League status.
IMAGES from the English Premier League matches played on Saturday
Images from action in the Spanish Super Cup and English Premier League
Chelsea put all their struggles away and looked like a renewed squad, stamping their class over Crystal Palace in their English Premier League match at the Selhurst Park on Sunday.
Five-time European champions Liverpool are in the quarter-finals of this year's competition
Images from the English Premier League matches played on Wednesday night.
A summary of Saturday's action in the Premier League.
Having spent much of his time at Chelsea operating in Eden Hazard's shadow, Willian has emerged as a leading light in the team ahead of their Champions League showdown with Barcelona.
Jose Mourinho's United side have 62 points and lead the Merseyside club by two with nine game remaining.
The Belgian international has scored 13 league goals this season, four in the Champions League and four in the FA Cup, but has been criticised for not being effective against the bigger teams in England.
Arsene Wenger's team look likely to return to Europe's most prestigious competition next season.
United's schedule contains 13 fixtures, including 11 league matches, but that total could potentially rise to 20 depending on their progress in the cup competitions.
Key to China's decision regarding Taiwan will be its leadership's assessment whether the US will come to Taiwan's defence, explains Jayadeva Ranade, the former senior RA&W officer and China expert.
Images from the English Premier League matches played on Sunday.
Images from the English Premier League matches played on Saturday.
Crystal Palace, who missed a stoppage-time penalty, became only the second team to take points off Manchester City in the English Premier League this season when they held the runaway leaders to a 0-0 draw at Selhurst Park on Sunday.
Rewind five years and Liverpool hosted Chelsea with three games remaining, knowing victory would have left them six points clear and a first league title since 1990 almost secure.
IMAGES from the EPL match played between Arsenal and Newcastle on Monday
Images from the English Premier League matches played on Saturday
'He has real technical quality and crucially, pace. But we can't be overly concerned with one player though because they have match winners all over the pitch. We need to nullify them on Wednesday.'
A preview of the line-up action in the English Premier League
Rodriguez whipped Everton in front from the edge of the box, and Michael Keane and Calvert-Lewin ensured it was two wins from two in the Premier League so far this season.
The following are talking points from the weekend's Premier League action:
The Croatian replaced Sam Allardyce in June 2015 and led the club to a seventh-placed finish in his first season. He also oversaw their move to the London Stadium last season, but has won just two out of 11 league games in the current campaign.
English Premier League leaders Liverpool will need to maintain their excellent recent record against Everton in Sunday's Merseyside derby if they are to hold their advantage over second-placed Manchester City.
Chelsea reacted angrily on Friday to newspaper reports that Carlo Ancelotti was set to replace manager Antonio Conte and that former coach Steve Holland has received texts from unhappy players who say they are missing him.
Real Madrid's Portugal striker Cristiano Ronaldo was crowned the best soccer player in the world for the second year running at FIFA's The Best awards gala on Monday.